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doi: 10.1113/jphysiol.2002.033811 55 ZhangJJinHZhangWDingCOKeeffeSYeMet al

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Moreover, GLP-1 exerts stabilizing effects on the endothelial contraction and barrier for AGE-treated endothelium via activating GLP-1R/cyclic adenosine monophosphate (cAMP)/PKA and inhibiting mitogen-activated protein kinase (MAPK) signaling pathways together with RAGE/Rho/ROCK [97, 98]

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