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Dysregulated NLRP3 produces pro-inflammatory cytokines, IL-1 and IL-18, which serve to exacerbate myocardial damage initiating widespread inflammation within the cardiac tissue The activation of the NLRP3 inflammasome is related to several high-risk factors of DCM such as hyperlipidaemia, diabetes, obesity and hyperhomocysteinemia (100)
If confirmed, endocrine evaluation is warranted before continuing treatment [8]
If the solution has settled or appears to have separated, gentle swirling is all that is needed to remix
This recurrence is attributed to the presence of residual tumor tissue and tumor stem cells which serve as the origin for future recurrences (105)
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