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In this situation, combination therapy shows unique advantages, CPT (an NRF2 inhibitor) (139), anti-angiogenic drugs (140), immune drugs (PD-1 inhibitors), etc
It may actually support hepatic redox balance" [11]
This timing supports optimal absorption and provides antioxidant defense against daily environmental stressors
Nanomolar of DON causes antioxidants (GSH) depletion and oxidative DNA damage, leading to reduced expression of heme oxygenase-1 (HO-1) (a homeostatic and protective agent against cellular stress) and loss of DNA reparative potential
Wei et al., 2012) (Figure 5)
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