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*(ML and CC are equivalent measurements) 5

freezing causes ice crystal formation that irreversibly shears peptide chains

Care is needed in patients with low potassium levels, certain blood disorders, or eye conditions

This reduced activity, combined with a potentially slower metabolism that can occur with persistent nutrient deficiencies, could indirectly contribute to weight gain over time

Avoid concurrent use unless directed by a healthcare provider

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision