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Orlowski M et al

[5] [4] Elevated homocysteine has been associated with cardiovascular concerns, though the clinical significance of supplementation remains under investigation

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doi:10.2174/1570159x1 3666160502153022

The scientific studies of these experimental drugs were never large enough or long enough to establish a clear safety profile, so all we are left with are vague reassurances from tiny studies and testimonials from YouTubers and TikTokers