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Vitamin B12 Deficiency Symptoms Deficiency may result in various disturbances such as hematological, neurological, and psychiatric problems, observed as the following symptoms: Feeling tired/weak or confused Tingling or numbness in fingers and toes Constipation, balance issues Depression and cognitive issues A swollen, inflamed tongue Anemia Deficiency symptoms tend to manifest gradually over a few years, and it is recommended to check blood serum levels for early detection [7]