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At these higher doses, the full triple-agonist mechanism is engaged

However, the effects on insulin sensitivity over long-term use are less well understood

Egan AG, Blind E, Dunder K, de Graeff PA, Hummer BT, Bourcier T, and Rosebraugh C

Considering CV health, little evidence described a detrimental effect of T replacement therapy, increasing CV risk [88,89] and adverse outcomes [90] , in particular in older men or in younger subjects with pre-existing heart diseases [89]