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large-scale randomised controlled trials in humans are lacking

Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway

Lauver DA, Kaissarian NM, Lucchesi BR

I.ParkM.KaangB.-K.et al (2017)

The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia

In this context, those effects are mediated via extracellular vesicles secreted by virally infected cells that contain viral effectors that modulate the metabolic activity of non-infected cells in the microenvironment