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At concentrations lower than those of DON, JHU395 has been found to decrease the growth and increase the apoptosis of high-MYC medulloblastoma cell lines, thereby prolonging the survival of treated animals ( GLS1 is the rate-limiting enzyme responsible for the breakdown of Gln
Many classes have been recognized so far, some of them with multiple members which may share sequence identities around 40%
Time to peak effect 2-5 min
Wang YR, Wang QH, Zhang T, Liu YH, Yao XQ, Zeng F, Li J, Zhou FY, Wang L, Yan JC, et al
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