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As with many things B12 related, we need more and better research on B12 metabolism , on the condition of PA and how to treat it most effectively

When circulation diminishes, follicles receive less oxygen, fewer growth factors, and inadequate building blocks for keratin production

doi:10.1067/mpd.2001.112160

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Indications: Addisonian pernicious anaemia

The most commonly reported events in active arms were mild and transient: injection site reactions in some subcutaneous subjects, occasional headache, and in some oral dosing arms, minor gastrointestinal tolerance issues