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10.1111/cts.12679 115 MilivojevicM.CheX.BatemanL.ChengA.GarciaB

In the Phase 2 OASIS trial, participants on the 12mg dose lost an average of 24.2% of their starting body weight over 48 weeks

Limit alcohol and fizzy drinks , which can cause bloating

Additionally, DPP-4 inhibitors such as linagliptin inhibit the receptor for Advanced glycation end products (RAGE) expression in keratinocytes, which can facilitate local vitamin D production by preventing interference from accumulated Advanced glycation end products (AGEs, 142)

In contrast, those with marked hyperglycemia or insulin resistance may achieve superior glycemic and weight outcomes with dual GLP-1/GIP agonists, such as tirzepatide, which combine potent insulinotropic and insulin-sensitizing effects

Redistribution of Blood Flow Physical activity levels and body composition can be impacted by weight loss and lowered appetite resulting from Semaglutide