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Subsequently, cytochrome c translocates from the mitochondrial intermembranous space into the cytoplasm, where they form the apoptosome and eventually trigger executioner caspases (104, 105)

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Before and during therapy, many clinicians in India increasingly recommend: Baseline and periodic kidney and liver tests Pancreatic enzymes where indicated An eye examination in diabetic patients An abdominal ultrasound in those at higher gallbladder risk What top experts and recent studies are saying Reviews in international journals stress that GI side effects are common but usually manageable, and that long-term benefits in diabetes and heart disease are substantial when the drugs are used correctly

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Discontinuation rates are higher among lower-income groups, those with multiple health conditions, and patients over 65