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Published in JAMA by Lippman and colleagues, it was stopped early when the results showed no reduction in prostate cancer risk in any group

2023 Jan 2;12(1)

Integrating insights from Su et al [79], this section explores the dual role of ferroptosis in both enhancing the sensitivity of tumor cells to radiation and contributing to radiation-induced damage in normal tissues

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As a result, this alteration stops Nrf2 from being ubiquitinated, which allows it to go into the nucleus and attach to antioxidant response elements (ARE) found in the promoter regions of antioxidant genes to increase their production

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