side effects of tirzepatide and semaglutide caused roughly half as many patients to stop treatment because gastrointestinal as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide tirzepatide gastrointestinal side effects compared

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Heitzer et al., 2000b

Yet, weight regain after treatment discontinuation is common and may undermine the long-term benefits unless proactively managed

Some people do exceptionally well on semaglutide, and semaglutide's results are still substantial and well established