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NNMT transfers a methyl group from SAM onto nicotinamide, producing 1-methylnicotinamide while consuming methyl donors and contributing to NAD depletion

This makes vitamin B12 deficiencies a particular concern for those following vegetarian or vegan diets

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Some people require regular doses over time, while others may only need short-term treatment to restore their levels

PT-141 (Bremelanotide) 14

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