The liver, which maintains the highest concentrations of glutathione in the body (5 to 10 mM), is the primary site of this detoxification activity
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The surge in popularity is also driven by the conflation of highly successful, legitimate therapeutic classeslike GLP-1 agonistswith entirely unrelated, unproven compounds
The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)
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