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Concurrent GH secretagogue and IGF1R agonist research uses compounds like CJC-1295/Ipamorelin alongside IGF-1 LR3 to study whether pulsatile endogenous GH/IGF-1 release combined with sustained IGF1R activation produces additive or synergistic effects on muscle, bone, or other target tissues

Guo C, Che X, Briese T, Ranjan A, Allicock O, Yates RA, et al

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Excess weight puts extra pressure on spinal joints, speeding up cartilage breakdown