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Topical GHK-Cu has decades of use in cosmetic formulations without significant reported adverse effects, and review literature describes it as generally well tolerated. The most commonly reported cosmetic side effect is temporary skin discoloration at the application site from copper oxidation, sometimes called copper uglies in skincare circles, which resolves after discontinuing use
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One older study from 2002 found that an emulsion containing 10% Argireline reduced wrinkle depth in women volunteers up to 30% after 30 days of treatment
Strasser A, OConnor L, Dixit VM
While absorption is slower, they remain a convenient and effective maintenant option
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