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Research shows that individuals gained from 0.9 to 1.8 pounds per month after stopping GLP-1 medications
It also offers Saxenda (liraglutide), a daily injectable GLP-1 that may appeal to users who prefer slower titration or want a daily routine
Focusing on individuals who had been treated with semaglutide 2.4 mg for 1 year introduced a potential selection bias, as these individuals were more likely to have experienced benefits and may have demonstrated higher adherence to the medication
Retrieved 8 June 2026
If that holds up in prospective studies, it changes how we think about this disease entirely, and this finding provides a strong rationale for further mechanistic and clinical studies focused on endometrial cancer prevention and treatment. The most dramatic drops in risk, where this reduction was by 50% or more, also occurred in multiple myeloma, pancreatic cancer, and colorectal cancer, in addition to endometrial cancer
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