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Life Sci 2025;362:123381

Sepsis-induced myocardial dysfunction (SIMD): the pathophysiological mechanisms and therapeutic strategies targeting mitochondria

FIGURE 2 The effects of GPX2 on oxidative stress are currently widely demonstrated.In the inflammatory response of bifidobacteria attenuating intestinal epithelial cells, upregulation of GPX2 can reduce oxidative stress and reduce the release of inflammatory factors (Yan and Chen, 2006).Therefore, GPX2 is believed to have the effect of oxidative stress and reducing the inflammatory response.The inhibitory effect of GPX2 on oxidative stress is a key link in inhibiting tumor development.Therefore, the antioxidant function of GPX2 may provide an early defense against the development of colon cancer.In studies on human colon cancer cells, GPX2 prevents inflammatory factor-driven carcinogenic processes by inhibiting the expression of COX-2 and mPGES-1 in human colon cancer cells and reducing inappropriate responses to inflammatory stimuli ( 2.3 GPX3 Glutathione peroxidase 3 (GPX3) is a tetramer, containing two of the four arginines bound to GSH, Arg103 and 185 (Nirgude and Choudhary, 2021)