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Therefore, the variation in IGFBPs expression is a crucial biomarker in breast tissue, for instance, high IGFBP-3 in TNBC is associated with poor prognosis, 103 while the loss of IGFBP-3, in vivo models, was associated with tumorigenic transformation
this finding is also aligned with the one reported from Friedrichsen et al
Regulation of cellular senescence via the FOXO4-p53 axis
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