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Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease
Nutrition ESPEN 61 , 427436 (2024)
RSL3 is a chloroacetamide-containing covalent ligand with two stereocenters, with only one of four stereoisomers displaying highly potent GPX4 inhibition 39
It hits all of WADAs aforementioned criteria for a banned substance
Pellets were thawed on ice for 1 h and lysed in 200 l 1% SDS in PBS supplemented with 1 protease inhibitors (cOmplete, EDTA-free Protease Inhibitor Cocktail, Roche, 11836153001) and shaken for 30 min at room temperature with 1:1,000 v/v benzonase nuclease (Sigma, E1014)