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Pharmacokinetic Parameters Clinical Uses Primary treatment of type 2 diabetes mellitus to reduce HbAc Chronic weight management in obesity or overweight individuals with risk factors Reduces risk of major adverse cardiovascular events in high-risk diabetic patients Adverse Effects Common: nausea, diarrhea, constipation, vomiting Less common: injection-site reactions, headache, dizziness Rare risk: pancreatitis

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Pscychostimulants Caffiene Drug Name: (generic), CDM, PJs, Liptons, 5 Hour Energy, Monster Energy, Starbucks Drug Class: CNS Stimulant, Methylxanthine Mechanism of Action: Adenosine receptor antagonist (leading to an increase in intracellular cAMP) Indications: Getting thru medical pharmacology lectures, sleep retardant, migraine, apnea of prematurity Side Effects: mild delirium insomnia diuresis dehydration tachycardia and fever commonly occur with overdosage more serious overdosage can cause cardiac arrhythmias and clonic-tonic convulsions FDA Adverse Events Report on Energy Drinks

Diabetes Care 39:861877 Pina L, Nguyen-Lee J, Wood GC et al (2025) Bariatric surgery significantly reduces progression from prediabetes to diabetes compared with the general population: 15-year single-institution data

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Carbon Monoxide (CO) as a Prohibited Method The use of rebreathing systems or equipment to deliver carbon monoxide is banned (M1.4)