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CSQ-tag enhanced solubility of four different therapeutic scFv in BL21(DE3) E.coli strain The CSQ-tag fusion with scFv was designed with calsequestrin (CSQ) at the N-terminus, followed by a flexible linker (GSEGSEGEGGSEGSEGEG), a TEV protease cleavage site, and a C-terminal single-chain variable fragment (scFv) (Fig

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Stimulates skin collagen: Collagen synthesis stimulation is one of GHK-Cus most consistently documented mechanisms

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Open-label, phase II study of talimogene laherparepvec plus pembrolizumab for the treatment of advanced melanoma that progressed on prior anti-PD-1 therapy: MASTERKEY-115

KPV acts directly on MC1R/MC4R receptors on macrophages and epithelial cells, reducing IL-6 and TNF- at the transcription level [7,8]