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These pathways followed by EGF activation are known to promote carcinogenesis in a wide variety of human solid tumors like epithelial malignancies, in which activated EGF signaling particularly through various mutations in EGFR plays an essential role [163]

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These findings collectively suggest that the role of CFTR activation as a promoter of intestinal cell proliferation is specific to the human premature intestine but not likely in the mouse intestine