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This activates NF-B to trigger neuroinflammation, ultimately exacerbating SNpc dopaminergic neuron apoptosis in PD (162)

Transit time through the small intestine extends

GLP-1 Receptor Agonists (GLP-1 RA) 2 GLP-1 (Glucagon-like peptide-1) GLP-1

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Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression