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Injection Technique General subcutaneous guidance from clinical best-practice resources [7] [8]

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Native human alpha-MSH is the 13-residue parent, Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH, with a methionine at position 4 that is the most oxidation-prone group in the molecule and an all-L backbone that peptidases cleave readily

DOI:10.1007/s00277-014-2050-z [ Links ] 45

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Both ATO and ATO lactone strongly bound to CYP3A4, with the lactone showing the highest affinity, which may delay metabolism and promote hepatic accumulation, aggravating oxidative stress and hepatotoxicity [51, 52]