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Normally GHK-Cu in its raw form is not overly effective orally as this tripeptide doesn't withstand the stomach acid nor the proteolytic enzymes in the stomach beyond at best 10-15% absorption

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This is why people with stomach surgery, autoimmune gastritis, or long-term PPI use can develop B12 deficiency despite adequate dietary intake

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However, mTOR which is activated by high energy activates the anabolic pathway and inhibits the catabolic pathway (Sangesa et al