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In clinical trials, it produced the most significant weight loss results of any FDA-approved medication to date averaging up to 22.5% of total body weight over 72 weeks

Reevaluate metabolic status prior to discontinuing and restarting GLP-1 therapy, measure HbA1c, electrolytes, and fasting glucose and document any insulin requirements to assist in safe resumption

Efficacy and safety of oral orforglipron in patients with type 2 diabetes: A multicentre, randomised, dose-response, phase 2 study

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Most side effects are temporary, but severe allergic reactions require immediate medical attention

A study reports that prophylactic liraglutide treatment reduces chronic inflammation (activated microglia) in the cortex and prevents memory impairment in APP/PS1 mice (143)