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The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of hyperglycaemia in these patients
However, the mechanism by which GLP-1R regulates the expression of p300 needs to be further investigated
Prevalence of hypogonadism in males aged at least 45 years: the HIM study
That has led to the fear that these agents might promote malignancies
Wainwright P, Narayanan S, Cook P Clinical biochemistry 2015
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