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Methotrexate is eliminated predominantly unchanged by the kidneys, with only minor hepatic metabolism
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The IC50 of paracetamol on normal hepatocytes was reduced from 2.221 to 1.527 mM after addition of BSO
Ishihara H, Takagi T, Kondo T, et al
Mild symptoms may improve with meal changes or slower escalation, while severe pain, vomiting, dehydration, or obstructive symptoms require urgent evaluation
And then I think about, you know, a lot of the rest of us that maybe started pretty thin and then as age came for natural reasons, you start to put on weight and if you're not really careful about it, you can be the person who's now in their 40s and has 25 extra pounds
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