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However, these applications are currently in the preclinical exploration stage, and large-scale clinical studies have yet to be conducted

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Conversely, a decrease in glucagon levels between baseline and follow-up assessment could present itself as an apparent increase in [ 68 Ga]Ga-DO3A-Tuna-2 binding due to reduced competition for binding

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The prosthetic-group modified pegylated arginase I is said to have further enhancement of enzyme stability, while there is claim that early pre-clinical studies of such modified formulation may be significantly more toxic than the pegylated native arginase I [151, 152]

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