Co-occurring conditions like depression, anxiety, or trauma need their own treatment
Protein binding is ~40%
Common qualifying conditions include high blood pressure, type 2 diabetes, prediabetes, high cholesterol, obstructive sleep apnea, and cardiovascular disease
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So, its best to be cautious.
Gallinaro JV, Gaparovi N, Rotter S (2022) Homeostatic control of synaptic rewiring in recurrent networks induces the formation of stable memory engrams