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The copper atom itself plays a role here, because copper-dependent enzymes such as superoxide dismutase (Cu/Zn-SOD) are central to endogenous antioxidant defense

10.1016/j.biomaterials.2012.12.009 Biomaterials 7 CharlierE.DeroyerC.CiregiaF.MalaiseO.NeuvilleS.PlenerZ.et al (2019)

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Aggregation changes the apparent molecular weight and can reduce bioactivity

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