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The evidence base for use of these drugs, either for off-label indications or as non-approved drugs, is wanting
The FDAs decision was supported by the Phase III SUNLIGHT trial, where the LonsurfAvastin combination led to a median overall survival of 10.8 months versus 7.5 months on Lonsurf monotherapy, for a 39% reduction in risk of death
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The current evidence suggests that sustained pharmacotherapy is necessary for most patients to maintain weight loss and prevent the metabolic adaptations that drive weight regain
It belongs to a group of drugs known as GLP-1 receptor agonists
Prioritize high protein intake, at least 0.8 to 1 gram per pound of goal body weight, to preserve muscle mass during weight loss
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