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In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)

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Venlafaxine , another selective norepinephrine and serotonin reuptake inhibitor, similar in effect to duloxetine but with slightly lower efficacy and less data from large studies [127]

The Big Picture: Why GLP-1 and Nutrition Are Inseparable GLP-1 medications do not function in isolationthey interact with dietary choices, gut-brain signaling, metabolic pathways, and hormonal responses