Semaglutide mimics a natural hormone called GLP-1 (glucagon-like peptide-1)
Third, confounding by indication may introduce channeling bias, since patients with advanced renal disease are often excluded from GLP-1 RA therapy, potentially creating an artificial appearance of protection
This process mixes food with digestive enzymes
Instead, hair changes observed during treatment more likely reflect the physiological effects of rapid weight loss, including calorie restriction, nutritional changes, and physiological stress
Additional risk factors include: Previous significant weight fluctuations or yo-yo dieting Genetic factors affecting skin quality and collagen production Smoking history, which impairs skin elasticity Inadequate protein intake during weight loss, leading to muscle loss Insufficient resistance exercise to maintain muscle mass Dehydration or poor nutritional status Patients with multiple risk factors should discuss realistic expectations with their GP or diabetes specialist nurse before commencing semaglutide therapy
Some patients may experience mild side effects, such as nausea, vomiting, diarrhea, or constipation, especially when first starting the treatment