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While no research yet shows a connection to Hashimotos, I wanted to make note that in some cases, individuals may have normal blood levels of folate, but the folate may not be getting to the brain due to autoimmune folate receptor antibodies (FRAs), which block the transport of folate into the cerebral spinal fluid (CSF)

These combined actions of GLP-1R signaling cause improvements in glycemic control as well as weight loss in type II diabetes (T2DM) patients treated with GLP-1R agonists

Together, these developments suggest that GLP-1RAs may become part of a broader obesity-directed strategy for selected patients with KOA

The American Journal of Medicine , 138 (6), 934-940

This dual-target approach allows for enhanced appetite suppression and metabolic improvement, leading to faster and more pronounced weight loss