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These outcomes lead to the remodeling of the extracellular matrix, oxidative stress, inflammation, cardiomyocyte apoptosis, fibrosis, and metabolic abnormalities [55]
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Also, mice carrying a genetic mutation that lack one of the igf1r alleles ( igf1r +/ ) show a 10 % reduction in post-natal growth, insulin resistance and glucose intolerance [237]
Glucose dysregulation
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