Iepsen EW, Lundgren JR, Hartmann B, et al
The two arms were reasonably well balanced with respect to the presence of cardiovascular comorbidities (angina, valvular disease, congestive heart failure, hypertension, diabetes, hyperlipidemia, and cardiac revascularization), with the placebo arm having marginally higher rates of cardiac arrhythmia (19% vs 11%), myocardial infarction (MI) (39% vs 30%), and obesity (BMI 30 kg/m 2 78% vs 66%)
Dysregulation of UPS in Huntingtons Disease HD patients manifest polyQ repeats of over 40 residues within the N-terminus of huntingtin protein
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