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Human safety is not established because large human trials have not been completed

J Invest Dermatol (2017) 137(4):9825

Increased catabolism of amino acids leads to the release of the amine group from amino acids whose carbon skeletons are used to replete intermediates of energy metabolism

Association between metformin and the risk of gastric cancer in patients with type 2 diabetes mellitus: a meta-analysis of cohort studies

To boost glutathione levels, people may consider consuming foods rich in the amino acids required for its synthesis, such as cysteine-containing foods (e.g., garlic, onions, cruciferous vegetables) or take glutathione supplements (though the effectiveness of oral supplementation is debated)

10.1111/bph.13426 112 WongK