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Counsel patients regarding the risk of medullary thyroid carcinoma and the symptoms of thyroid tumors

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FOXO4-DRI treatment in chemotherapy-treated mice resulted in faster recovery of tissue function, reduced inflammatory markers, and improved physical performance compared to untreated controls

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The oral version is taken once daily on an empty stomach, at least 30 minutes before food

Tier 3 (Recommended): Bone-age radiograph, IGF-1 and IGFBP-3 levels, thyroid function panel, and a validated depression/anxiety screen (PHQ-A for adolescents) before treatment initiation