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2017;313:L491506

Physiological roles of mitochondrial reactive oxygen species

Ishizawa J, Zhao R, Heese L, Jaeger A, Nishida Y, Jacamo RO, Kojima K, John Ma MC, Ruvolo V, Chachad D, Devine W, Lindquist S, Davis R, Porco JA, Jr, Whitesell L, Andreeff AM

Protection Against Oxidative and Cellular Aging : GHK-Cu exerts cytoprotective effects by chelating free copper ions and reducing oxidative damage to lipids, proteins, and DNA

To mitigate this stress, tumor cells activate robust antioxidant systems that neutralize ROS and sustain redox stability [6]

Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38