The long-term sc administration of exendin-4 decreased daily food intake and practically blocked weight gain in obese rats
It is FDA-approved to manage type 2 diabetes and reduce cardiovascular risks in people with diabetes and heart disease
Nathanson D, Ullman B, Lfstrm U, Hedman A, Frick M, Sjholm A, Nystrm T: Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety
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Am J Physiol Endocrinol Metab 303(1):E103E110 Hatoum IJ et al (2012) Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery