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Tirzepatide is a dual agonist that activates both GIP and GLP-1 receptors, which is thought to explain its larger average weight loss in clinical trials
PMID: 23992601
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The GH elevation protects lean mass, allowing fat loss without the metabolic slowdown that accompanies aggressive restriction
Severe gastrointestinal reactions are now listed as a side effect
The advantage of lower doses is dramatically reduced side effect burden
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