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Venlafaxine is a CYP2D6 substrate, converted to its active metabolite O-desmethylvenlafaxine (desvenlafaxine) via CYP2D6 [6]

Glutathione depletion and impaired glutathione peroxidase (GPx) activity are documented in autoimmune thyroid patients

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It binds to transcobalamin II , helping vitamin B12 reach tissues

You can ask your GP if they can prescribe semaglutide, or if they can send a referral to an NHS weight management specialist service who can prescribe Wegovy instead

95% CI [1.181.49]) and mortality (aOR 1.36