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The further addition of GCGR agonism in retatrutide introduces Gs-cAMP signalling in hepatocytes, brown adipose tissue, and the central nervous system cell types with limited or no GLP-1R or GIPR expression expanding the tissue scope of the compound's action profile

Elevated fumarate has been implicated in metabolic and respiratory diseases, such as airway obstruction and diabetes [83, 84]

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Among these polysaccharide metabolites, plant-derived polysaccharides show great potential for application in dietary intervention and disease treatment, and they are considered as highly promising metabolites for replacing conventional therapeutic drugs (Wang H