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Dietary Recommendations for the Management of Gastrointestinal Symptoms in Patients Treated with GLP-1 Receptor Agonist
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They are all small molecules which act as reversible competitive inhibitors of the catalytic activity of DPP-4 and, when used at the appropriate therapeutic dose, are associated with at least 70% inhibition of plasma DPP-4 activity (35) (although the actual extent of inhibition in vivo is likely to be higher, due to dilution of the inhibitor in the ex vivo assay)
Because acyl-carnitine is derived from the metabolism of fatty acids and organic acids, it is reasonable that abnormal systemic fatty acid oxidation readily leads to gut-specific toxicity after the introduction of a metabolic challenge with enteral feeding
U., and Weidner, W
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