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Importantly, pre-administration of LASSS to mice prevented the disuse-induced HGF nitration observed in a tail-suspension model for muscle atrophy, while GSSSG did not
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Given the prior evidence for lower GSH levels in patients with MDD, our hypothesis is that glutathione levels may be lower in patients compared to healthy controls and that these differences may be brain-region specific
To this end, it is important noting that the major risk factors for severe COVID-19 illness are aging, comorbidities, smoking habit, all characterized by intrinsically low antioxidant capacity and high ROS/GSH ratios (Polonikov, 2020) (see Figure 1 )
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