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Research-Observed Effects Studies in animal models have documented various research-observed responses including nausea, decreased appetite, and yawning behaviors, often linked to MC-4R activation pathways

But levels of the compound it is made from, L-carnitine, decline with age

Large doses can also increase the likelihood of oxalate stones in the urinary tract in patients with a history of nephrolithiasis, hyperoxaluria, or oxalosis